Funeral directory for Dec. 29, 2011 The Daily News Online Barth, Richard A. â€" There is no prior visitation. An anatomical gift to Boonshoft School of Medicine, Wright University, Daynton, Ohio was given. A memorial service will be at 6 pm Monday at Northgate Free Methodist Church, South Campus, 250 Bank St., ... |
Thursday, December 29, 2011
Funeral directory for Dec. 29, 2011 - The Daily News Online
edovogopu.wordpress.com
Tuesday, December 27, 2011
Pedal to Properties takes on partner, plans expansion - Memphis Business Journal:
pabigy.wordpress.com
Founded and headed by Matt Pedal to Properties is a residential real estatwe firm that gives clients the optionm of looking at homes by The company maintains a fleet of 50 Electra Cruiser bikes. Kolb has sold a 50 perceng stake in the companuy for an undisclosed sum to attorneyTim Majors, who specializee in taking regional retail businesses national. As a partner in Pedal to Majors will work out ofthe company’e Boulder office. Majors, who’s originally from Perth, Australia, approached Kolb abouy investing in the real estats firm after looking at Boulder propertiesby bicycle.
“We certainlu plan to incorporate [Tim’s] national and international brandin expertise to expand Pedal to Properties inothedr markets,” Kolb said in a statement. Pedal to Propertieds plans to look at opening brancu officesin other, unspecified U.S. markets. In May, the company launched a licensee designation for brokers interested in usinf theBoulder business’ operational formula in their The Colorado company already is working to expanrd quickly in its hometown by addiny more space and agents in downtown “I believe Pedal to Properties is in a perfect position to meet the evolving social and demographic change s going on in the United States with homebuyers,” Majorx said in a statement.
Founded and headed by Matt Pedal to Properties is a residential real estatwe firm that gives clients the optionm of looking at homes by The company maintains a fleet of 50 Electra Cruiser bikes. Kolb has sold a 50 perceng stake in the companuy for an undisclosed sum to attorneyTim Majors, who specializee in taking regional retail businesses national. As a partner in Pedal to Majors will work out ofthe company’e Boulder office. Majors, who’s originally from Perth, Australia, approached Kolb abouy investing in the real estats firm after looking at Boulder propertiesby bicycle.
“We certainlu plan to incorporate [Tim’s] national and international brandin expertise to expand Pedal to Properties inothedr markets,” Kolb said in a statement. Pedal to Propertieds plans to look at opening brancu officesin other, unspecified U.S. markets. In May, the company launched a licensee designation for brokers interested in usinf theBoulder business’ operational formula in their The Colorado company already is working to expanrd quickly in its hometown by addiny more space and agents in downtown “I believe Pedal to Properties is in a perfect position to meet the evolving social and demographic change s going on in the United States with homebuyers,” Majorx said in a statement.
Sunday, December 25, 2011
Supreme Court temporarily blocks Chrysler/Fiat merger - Business First of Buffalo:
haga-aa8xuq.blogspot.com
Supreme Court Justice Ruth Bader Ginsberg granted a motionb filed by Indiana state pensionj funds to delay the mergee between the American and Italian automakeres in whatthe U.S. Treasury Departmentf said was an administrative extensionn designed to allow sufficient time for the Supreme Court to explore whether or not a stayis needed, accordint to several published reports late The Supreme Court move extenda a stay already issued by a lowed court that was set to expirew late afternoon Monday. Fiat has given Chrysler until June 15 to finisbthe merger. Attorneys for the pensionj funds argued that they woulcd receive just pennies on the dollar fora $42 milliomn loan given to Chrysler.
However, U.S. Solicito General Elena Kagan said the imminent collapswe ofChrysler — said to be losing upward of $100 milliobn daily — was of greater concernb to government officials than the loan When Chrysler filed for it announcee it would reject 789 dealership agreements including nine in the St. Loui s metro area. Chrysler’s restructuring plan also calls for closinveight plants, including Chrysler’xs two plants in Fenton, Mo. Chrysler’s South plant in Fenton, which assemblesd minivans, was idled at the end of October.
Chrysler’s Nortu plant, which makes Dodge Ram trucks, was idled earliere this month for one to two montha and The plants hademployed 1,200 workers in down from 5,000 several years ago.
Supreme Court Justice Ruth Bader Ginsberg granted a motionb filed by Indiana state pensionj funds to delay the mergee between the American and Italian automakeres in whatthe U.S. Treasury Departmentf said was an administrative extensionn designed to allow sufficient time for the Supreme Court to explore whether or not a stayis needed, accordint to several published reports late The Supreme Court move extenda a stay already issued by a lowed court that was set to expirew late afternoon Monday. Fiat has given Chrysler until June 15 to finisbthe merger. Attorneys for the pensionj funds argued that they woulcd receive just pennies on the dollar fora $42 milliomn loan given to Chrysler.
However, U.S. Solicito General Elena Kagan said the imminent collapswe ofChrysler — said to be losing upward of $100 milliobn daily — was of greater concernb to government officials than the loan When Chrysler filed for it announcee it would reject 789 dealership agreements including nine in the St. Loui s metro area. Chrysler’s restructuring plan also calls for closinveight plants, including Chrysler’xs two plants in Fenton, Mo. Chrysler’s South plant in Fenton, which assemblesd minivans, was idled at the end of October.
Chrysler’s Nortu plant, which makes Dodge Ram trucks, was idled earliere this month for one to two montha and The plants hademployed 1,200 workers in down from 5,000 several years ago.
Friday, December 23, 2011
Black, Foamy Water Worries Fracking Neighbors - Voice of America
tosece.blogspot.com
The State | Black, Foamy Water Worries Fracking Neighbors Voice of America December 12, 2011 Black, Foamy Water Worries Fracking Neighbors Extraction of natural cause draws health concerns in Pennsylvania Rosanne Skirble | Southwestern Pennsylvania There is a lot of construction near Janet McIntyre's home in southwestern ... Fracking Opens Fiss ures Among States as Drillers Face Many Rules As shale fracking booms, environmental protection lags Shale Gas: Time to Look Before We Leap Any Further |
Wednesday, December 21, 2011
More Bay Area journalists to lose jobs - San Francisco Business Times:
sucujovide.wordpress.com
Revenue continues to slide forthe - East Bay, whichb includes the and , among other according to a memo from BANG-EB Executive Editor Kevin Keane that was postede on media blogs. “I had always held out hope that businessw would bounce back quickly enough that we would be able to avoid furthed staff reductions thisfiscal year,” Keane wrote. "Todagy we're announcing that we will be eliminatintg18 full-time positions in the newsroom (managers and rank and file by mid summer.
" Laid-off employees will get a week’sw pay for each year worked, up to 12 Employees who volunteer to be laid off would get up to an extrwa eight weeks pay, at one week’s pay per year Employees have until Wednesday to volunteer. The compant won’t challenge unemployment benefits for thoswe who volunteer for according to the MediaWorker Guild, the union representing newsroom employees. BANG-EB is ownee by MediaNews, the Denve media conglomerate that also ownsthe , the and othe r Bay Area newspapers.
Revenue continues to slide forthe - East Bay, whichb includes the and , among other according to a memo from BANG-EB Executive Editor Kevin Keane that was postede on media blogs. “I had always held out hope that businessw would bounce back quickly enough that we would be able to avoid furthed staff reductions thisfiscal year,” Keane wrote. "Todagy we're announcing that we will be eliminatintg18 full-time positions in the newsroom (managers and rank and file by mid summer.
" Laid-off employees will get a week’sw pay for each year worked, up to 12 Employees who volunteer to be laid off would get up to an extrwa eight weeks pay, at one week’s pay per year Employees have until Wednesday to volunteer. The compant won’t challenge unemployment benefits for thoswe who volunteer for according to the MediaWorker Guild, the union representing newsroom employees. BANG-EB is ownee by MediaNews, the Denve media conglomerate that also ownsthe , the and othe r Bay Area newspapers.
Monday, December 19, 2011
Ramsay stepping down as president of University of Maryland, Baltimore - The Business Review (Albany):
dyakonostrlin.blogspot.com
During his tenure, Ramsay was instrumental in launching the ambitious UMB BioPar andthe university’s west-side expansion efforts. In a letter to Ramsay said he would step down once the selectsxhis successor. “Until that time I shall continue to servre this campus to the best of my ability so that the comingy year will be at leasft as productive as what has gone Ramsay said inthe letter. Ramsay has grown UMB into a top-notch research institution, said University System of Maryland ChancellodrWilliam E.
“Brit” “It’s a different place than what hecame to,” Kirwan “He came in with a real missionh of building the quality of the institution and he has done that in an exceptionak fashion.” Kirwan said he will form a search committee to find Ramsay’s The process could take anywherwe from a few months to a year. Ramsay, 70, is the past chait of the Association of Academifc Health Centers and was recently appointed its firstforeign secretary. He also serves on the boardes ofthe , the Downtowj Partnership of Baltimore Inc.
, the and the in
During his tenure, Ramsay was instrumental in launching the ambitious UMB BioPar andthe university’s west-side expansion efforts. In a letter to Ramsay said he would step down once the selectsxhis successor. “Until that time I shall continue to servre this campus to the best of my ability so that the comingy year will be at leasft as productive as what has gone Ramsay said inthe letter. Ramsay has grown UMB into a top-notch research institution, said University System of Maryland ChancellodrWilliam E.
“Brit” “It’s a different place than what hecame to,” Kirwan “He came in with a real missionh of building the quality of the institution and he has done that in an exceptionak fashion.” Kirwan said he will form a search committee to find Ramsay’s The process could take anywherwe from a few months to a year. Ramsay, 70, is the past chait of the Association of Academifc Health Centers and was recently appointed its firstforeign secretary. He also serves on the boardes ofthe , the Downtowj Partnership of Baltimore Inc.
, the and the in
Friday, December 16, 2011
F.N.B. appoints Campbell as chairman - Kansas City Business Journal:
afanasenkobexa.blogspot.com
Campbell formerly served as F.N.B.’s (NYSE:FNB) lead directore and serves on several He has been a directorsince 1975. “Bill is one of our longest serving and most dedicated Gurgovits said ina statement. previously said it would appoingt a new chairman to enablwe Gurgovits to focus on his corporate responsibilities and to confornmto F.N.B.’s corporate guidelines. Gurgovits, who has workexd at F.N.B. for 48 years, had taken the chairman role in April 2008 when Roberft New was named CEO and president afted anearly two-year search. New resigned 10 months later and Gurgovitsw stepped back in on an interim basis initially. He accepted the post fulltime onJune 2.
is based in Hermitage, north of Pittsburgh, and had assetse of $8.5 billion as of March 31.
Campbell formerly served as F.N.B.’s (NYSE:FNB) lead directore and serves on several He has been a directorsince 1975. “Bill is one of our longest serving and most dedicated Gurgovits said ina statement. previously said it would appoingt a new chairman to enablwe Gurgovits to focus on his corporate responsibilities and to confornmto F.N.B.’s corporate guidelines. Gurgovits, who has workexd at F.N.B. for 48 years, had taken the chairman role in April 2008 when Roberft New was named CEO and president afted anearly two-year search. New resigned 10 months later and Gurgovitsw stepped back in on an interim basis initially. He accepted the post fulltime onJune 2.
is based in Hermitage, north of Pittsburgh, and had assetse of $8.5 billion as of March 31.
Wednesday, December 14, 2011
Payroll-Tax Stalemate Lets Democrats, GOP Underscore Key 2012 Messages - NPR (blog)
doqujamup.wordpress.com
Payroll-Tax Stalemate Lets Democrats, GOP Underscore Key 2012 Messages NPR (blog) Whether Democrats win or lose on the payroll tax front, fighting for it is a key part of their message. Democrats have also argued, with support from numerous economists, that it would damage the economy to withdraw spending power from consumers right ... |
Monday, December 12, 2011
Center stage: Tamarind hopes to spur art at new digs - San Antonio Business Journal:
inofiquxi.wordpress.com
Marjorie Devon, executive director of the , says when water pools on her preseroom floor, it's not unusual for toy boatz or miniature mermaids to appear. But Devon looks forward to the day when the institut is in a building with a proper heating and ventilation system and sophisticatesd temperature controls to protect the uniqu e prints created within its And she hopes the window s facing Central will offer opportunitie to show some of the work Tamarind Renowned internationally as a center of Tamarind is preparing for a move fromits low-keuy spot at 110 Cornell SE to a far more visibler and prestigious location on Central Avenure directly across from the .
Tamarindd is in the middle of a $5 millionj capital campaign and hopes to be in the new siteby 2010. The buildinf at Central and Stanford hashouser UNM's School of Architecture & Planning, whicuh is moving onto the main campus. Preliminary designs created by architect Devendra Contractort would transform the building with open windowss onto Central and a third floor apartmen for artistsin residence. A slab of concrete in the middlre might be clad in limestone from the same quarry whers the inventorof lithography, Aloias Senefelder, got his first stone in 1798. Tamarinrd will have about 16,000 square feet of spacde versus 9,000.
"The building is at the gateway to the universityt and right in the middleof Albuquerque's culturalk corridor," Devon says. "I hope it will give impetus to art developmeng inthat area." Devon adds she would love to see more galleriesd cluster in that area as well. New infrastructure couldd bring Web streaming capabilities for workshopaas well. Tamarind will have spacre for a donated which will allow it to printr book projects by artists rather thanoutsourcinh them. The building will include an expanded gallery for print which Tamarind uses to support itseducationao programs. Only about one third of its operating budget comesfrom UNM.
So far it has raiser $930,000 from the Legislature and Devo plans to seekanother $1.5 million in the next sessiob for the building. A pending bond at UNM woulsd bringanother $1.5 million. Tamarind is require by UNM to raise $1 milliojn from private donors as To date, it has raised Artist Ed Ruscha did a benefit print for the all copies of which were UNM allowed the nonprofit to keep the $550,0090 from the sale of its current building. The universith sold the building earlieer this year to Larry owner ofthe , who plans to use it for supportr operations. Tamarind will be allowed to stay, rent-free, for threes years.
Among the corporate donors Tamarinf has attractedare , and "W see art as the foundation of Albuquerque," says Lind Wedeen, spokeswoman for First the lead donor. "Someplace like Tamarindr that has been around for so many years and is nationallu known really is a jewel for usand we'rre happy to support that." Tamarind started up in 1960 in Los Angelesa as a center for reviving the art of lithography. It moved to Albuquerque in 1970, and became part of UNM'z College of Fine Arts.
It has traines hundreds of lithographers from aroundthe Tamarind's specialty is the training of master printmakers who work in a collaborativwe effort with artists to create unique Lithographs are prints made usinvg a press to transfer an image that was createxd initially on stone or metal platee to paper. The institute has worked with hundredsof artists, most recentluy Jim Dine, and a series of works by Americajn Indian artists sent by the . Thos e prints will hang in the residencezof U.S.
ambassadors around the
Marjorie Devon, executive director of the , says when water pools on her preseroom floor, it's not unusual for toy boatz or miniature mermaids to appear. But Devon looks forward to the day when the institut is in a building with a proper heating and ventilation system and sophisticatesd temperature controls to protect the uniqu e prints created within its And she hopes the window s facing Central will offer opportunitie to show some of the work Tamarind Renowned internationally as a center of Tamarind is preparing for a move fromits low-keuy spot at 110 Cornell SE to a far more visibler and prestigious location on Central Avenure directly across from the .
Tamarindd is in the middle of a $5 millionj capital campaign and hopes to be in the new siteby 2010. The buildinf at Central and Stanford hashouser UNM's School of Architecture & Planning, whicuh is moving onto the main campus. Preliminary designs created by architect Devendra Contractort would transform the building with open windowss onto Central and a third floor apartmen for artistsin residence. A slab of concrete in the middlre might be clad in limestone from the same quarry whers the inventorof lithography, Aloias Senefelder, got his first stone in 1798. Tamarinrd will have about 16,000 square feet of spacde versus 9,000.
"The building is at the gateway to the universityt and right in the middleof Albuquerque's culturalk corridor," Devon says. "I hope it will give impetus to art developmeng inthat area." Devon adds she would love to see more galleriesd cluster in that area as well. New infrastructure couldd bring Web streaming capabilities for workshopaas well. Tamarind will have spacre for a donated which will allow it to printr book projects by artists rather thanoutsourcinh them. The building will include an expanded gallery for print which Tamarind uses to support itseducationao programs. Only about one third of its operating budget comesfrom UNM.
So far it has raiser $930,000 from the Legislature and Devo plans to seekanother $1.5 million in the next sessiob for the building. A pending bond at UNM woulsd bringanother $1.5 million. Tamarind is require by UNM to raise $1 milliojn from private donors as To date, it has raised Artist Ed Ruscha did a benefit print for the all copies of which were UNM allowed the nonprofit to keep the $550,0090 from the sale of its current building. The universith sold the building earlieer this year to Larry owner ofthe , who plans to use it for supportr operations. Tamarind will be allowed to stay, rent-free, for threes years.
Among the corporate donors Tamarinf has attractedare , and "W see art as the foundation of Albuquerque," says Lind Wedeen, spokeswoman for First the lead donor. "Someplace like Tamarindr that has been around for so many years and is nationallu known really is a jewel for usand we'rre happy to support that." Tamarind started up in 1960 in Los Angelesa as a center for reviving the art of lithography. It moved to Albuquerque in 1970, and became part of UNM'z College of Fine Arts.
It has traines hundreds of lithographers from aroundthe Tamarind's specialty is the training of master printmakers who work in a collaborativwe effort with artists to create unique Lithographs are prints made usinvg a press to transfer an image that was createxd initially on stone or metal platee to paper. The institute has worked with hundredsof artists, most recentluy Jim Dine, and a series of works by Americajn Indian artists sent by the . Thos e prints will hang in the residencezof U.S.
ambassadors around the
Saturday, December 10, 2011
Advancing Gay and Transgender Equality Abroad - Center For American Progress
obofym.wordpress.com
Center For American Progress | Advancing Gay and Transgender Equality Abroad Center For American Progress By Jeff Krehely | December 9, 2011 On Tuesday this week, the Obama administration took two huge steps in advancing the human rights of gay and transgender people around the globe.(1) First, President Barack Obama issued a presidential memorandum titled ... Deciphering the truth and consequences of Obama's global LGBT policy Rights and wrongs The Real Ugly American |
Thursday, December 8, 2011
Weight Loss With Qnexa Stops Progression Toward Type 2 Diabetes in Obese Non-Diabetic Patients
stony-coating.blogspot.com
After 28 weeks of blood sugar levels, as measured by hemoglobin A1c (HbA1c), were lower in the patient treatedwith Qnexa, while the patients in the placebo group had a significant increase in their HbA1c levelzs (p<0.0001). The placebo-adjusted reductions in HbA1c for patients taking Qnex awere 0.11 percent and 0.10 percent for the full-dose and mid-dosd groups (p<0.0001). If HbA1c trajectories during this study were theaverage placebo-treated patient would develop diabetes, per guidelines established by the Americann Diabetes Association (ADA), in approximatelyg eight years. Patients treated with Qnexw had weight lossof 9.2% and 8.
5% on the full-dosr and mid-dose of Qnexa as compared to weight loss of 1.7% in the placebok group (p<0.001). These findings (abstract 119-OR) are being presented by , MD, Clinical Professotr of Medicineat Weill-Cornell University and Director of New York Presbyteriaj Hospital's Comprehensive Weight Control Program, and a lead investigatoe in the study, at the 69th Scientific Sessionse of the ADA. The podium presentatio n will take place during the Novel Diabetes Treatmentx in Development in Humans Sessionfrom 4:00-6:00 locaol time. Dr. Aronne stated, "Obesity is the leadinvg cause of type2 diabetes.
Studiezs have shown that type 2 diabetes can be treated effectivelyg in most patients with significant weight People with weight problems have a disease that can be obesity is more about biology and nota person'sa lack of will power, and we are in desperats need of more effective tools to help our patientxs combat this disease and the othedr serious medical conditions that arise as a resulg of weight gain. Theser study results suggest that Qnexqa is a promising pharmaceutical therapy to assistt patients in achieving weight loss and to halt the progressiojn towards type2 diabetes.
Whild the study was designed as an obesity the positive impact on glycemic endpointz suggests potential health benefits inthe non-diabetic obeser population." "Data from DM-230 showed that treatment with Qnexw will lower HbA1c in diabetic patients, but we now know that for patiente that have not been diagnosed with diabetes, Qnexsa treatment can prevent increases in HbA1c levels. Obesity is the commob cause of type 2 diabetes and other metabolicf andcardiovascular diseases. In this study, treatment with Qnexa arrestedf progression todiabetes completely.
These data highlight the importany but often underappreciated potential of treatingt the major cause of diabetes before the diseasebecomese apparent," said , president and chiedf executive officer of "We expect the CONQUER study, a large ongoin phase 3 study that includes diabetid and pre-diabetic subjects, will further demonstrate the efficacyy of Qnexa for weight loss and effectivre management of glycemic control in diabetic and non-diabetic patients.
" "The clinical program has been carefull designed to test the safety and efficac y of Qnexa in a wide rangde of healthy and co-morbid obese With the high hurdles of benefit/riski set by regulatory and reimbursement authorities, it's not enoug h for a drug to demonstrate weight loss; new obesitgy drugs should have the potential for impacting an importany down-stream consequence of obesity, diabetes. We are excited to see the resultds of the first phase 3 trial supportinvthis goal," said , Ph.D., vice president clinical development at The EQUATE study included 756 obese patients (599 females and 157 across 32 centers in the United States.
The averagwe baseline BMI of the study populationwas 36.3 kg/m2w and baseline weight was 101.3 kg. The study was a double-blind, placebo-controlled, prospective trial with subjectxs randomized toreceive once-a-dag treatment with mid-dose Qnexa (7.5 mg phentermine/46 mg topiramat e CR), full-dose Qnexa (15 mg phentermine/92 mg topiramate CR), the respectivew phentermine and controlled-release topiramate constituents, or placebo. Patientd had a four-week dose titration period followeed by 24 weeksof treatment. Subjects were asked to follow a hypocaloric diet representinva 500-calorie/day deficit and advisex to implement a simplwe lifestyle modification program.
The study found that nearluy two-thirds (66%) of patients treated with Qnexa lost 5 percent or more of theifr initial body weight atthe drug's full dose, 62 percent for mid-dosse and 15 percent for placebo. The proportiohn of Qnexa patients losing 10 percentg or more of their initial body weighgt was 41 percent for 39 percentfor mid-dose and 7 percent for Nearly one-fifth (19%) and 15 percent of the patientz lost at least 15 percent of their body weighty on the full-dose and mid-dose of Qnexaw as compared to 2 percent for the placebo Results were evaluated using ITT-LOCF, the method of analysis requiredx by the U.S. Food and Drug Administration.
Qnexas was well-tolerated, with no drug-related serious adverse events. The most commoj adverse events reported forthe mid-dose and placebo group were dry mouth, altered taste and constipation. The completioj rate for the studyu overall was70 percent. More than 300 milliomn people worldwide and approximatelty 30 percent of Americanadults (more than 60 millionb people) are obese, a chronic condition definesd by having excess body fat. As the seconxd leading cause ofpreventable death, obesity directly contributes to numerous life-threatening conditionsw including diabetes, cardiovascular disease, hypertension and stroke.
Experts agree that even a modesyt weight loss of five percentof weight, maintained over time, can bringv significant health benefits by lowering bloodr pressure and reducing the risk of diabete s and heart disease. Pre-diabetes is a conditionn where blood glucose levels are higher than normal but not yet high enoughb for the patient to be diagnosexdwith diabetes. Blood glucose levels are considered to be norma when Fasting PlasmaGlucose (FPG) is below 100 mg/dL. There are 57 million people in the United Statee and 314 million worldwidew whohave pre-diabetes.
Recent researchb has shown that long-term damagew to the body, especially the heart and circulatory may already be occurringduring pre-diabetes. Baselinre HbA1c levels were 5.48 percent and 5.42 percentr for the full-dose and mid-dos groups. The ADA guideline s suggest that HbA1c levels shouldbe 7.0 percent or Qnexa (Q-NEX-uh) is a proprietary, low controlled release formulation of phentermine and topiramate that simultaneousluy addresses both appetite and satiety -- the two main mechanisms that impacgt eating behavior -- in one daily Qnexa, an investigational drug, is an obesityg therapy being developed to addresw type 2 diabetes as well as weight loss.
In phasse 2 and phase 3 clinical trials to Qnexa has demonstrated significant weight glycemic control, and improvement in cardiovascula r risk factors. Qnexa is well with no drug-related serious adverse events reported to VIVUS is a biopharmaceutical companydeveloping next-generation therapies to address unmet needs in obesity, diabetes and sexuall health. The company's lead product in clinical development, is expected to complete phase 3 clinical trials for the treatmenr of obesityin 2009. Qnexa is also in phase 2 clinicak development for the treatment of type2 diabetes.
In the area of sexua l health, VIVUS is in phase 3 developmengtwith avanafil, a potentially best-in-class PDE5 inhibitor, and in phasew 2 development of Luramist(TM) for the treatment of hypoactive sexual desire disorder (HSDD) in women. (alprostadil), a first generation therapy for the treatmengof ED, is already on the market and generating revenue for VIVUS. For more information about the company, pleasr visit . Certain statements in this press releas eare forward-looking within the meaning of the Private Securitiee Litigation Reform Act of 1995.
These statemente may be identified by the useof forward-lookinv words such as "anticipate," "believe," "forecast,"" "estimated" and "intend," among others. These forward-lookinbg statements are based on VIVUS' current expectations and actual results coulddiffer materially. There are a number of factors that coul cause actual events to differ materially from those indicated bysuch forward-lookinbg statements.
These factors include, but are not limitedd to, substantial competition; uncertainties of patent protectionand litigation; uncertainties of governmenrt or third party payer reimbursement; reliance on sole source suppliers; limitee sales and marketing efforts and dependence upon thirdf parties; risks related to the development of innovative and risks related to failure to obtain FDA clearancesz or approvals and noncompliance with FDA regulations. As with any pharmaceutica under development, there are significan t risks inthe development, regulatory approval and commercialization of new products.
There are no guarantee s that future clinical studieas discussed in this press released will be completed or successful or that any produc t will receive regulatory approval for any indication or provee to becommercially successful. VIVUS does not undertakw an obligation to update or reviseany forward-lookinfg statement. Investors should read the risk factors set forthbin VIVUS' Form 10-K for the year endedr December 31, 2008 and periodic reports filex with the Securities and Exchange Commission. VIVUS, Inc. Investor Relations: The Trout Groupo Timothy E. Morris Brian Korb Chief FinancialOfficer 646-378-29233 650-934-5200 Media Relations: Pure Communications, Inc.
Jennifert Torres 312-624-9802 SOURCE VIVUS, Inc.
After 28 weeks of blood sugar levels, as measured by hemoglobin A1c (HbA1c), were lower in the patient treatedwith Qnexa, while the patients in the placebo group had a significant increase in their HbA1c levelzs (p<0.0001). The placebo-adjusted reductions in HbA1c for patients taking Qnex awere 0.11 percent and 0.10 percent for the full-dose and mid-dosd groups (p<0.0001). If HbA1c trajectories during this study were theaverage placebo-treated patient would develop diabetes, per guidelines established by the Americann Diabetes Association (ADA), in approximatelyg eight years. Patients treated with Qnexw had weight lossof 9.2% and 8.
5% on the full-dosr and mid-dose of Qnexa as compared to weight loss of 1.7% in the placebok group (p<0.001). These findings (abstract 119-OR) are being presented by , MD, Clinical Professotr of Medicineat Weill-Cornell University and Director of New York Presbyteriaj Hospital's Comprehensive Weight Control Program, and a lead investigatoe in the study, at the 69th Scientific Sessionse of the ADA. The podium presentatio n will take place during the Novel Diabetes Treatmentx in Development in Humans Sessionfrom 4:00-6:00 locaol time. Dr. Aronne stated, "Obesity is the leadinvg cause of type2 diabetes.
Studiezs have shown that type 2 diabetes can be treated effectivelyg in most patients with significant weight People with weight problems have a disease that can be obesity is more about biology and nota person'sa lack of will power, and we are in desperats need of more effective tools to help our patientxs combat this disease and the othedr serious medical conditions that arise as a resulg of weight gain. Theser study results suggest that Qnexqa is a promising pharmaceutical therapy to assistt patients in achieving weight loss and to halt the progressiojn towards type2 diabetes.
Whild the study was designed as an obesity the positive impact on glycemic endpointz suggests potential health benefits inthe non-diabetic obeser population." "Data from DM-230 showed that treatment with Qnexw will lower HbA1c in diabetic patients, but we now know that for patiente that have not been diagnosed with diabetes, Qnexsa treatment can prevent increases in HbA1c levels. Obesity is the commob cause of type 2 diabetes and other metabolicf andcardiovascular diseases. In this study, treatment with Qnexa arrestedf progression todiabetes completely.
These data highlight the importany but often underappreciated potential of treatingt the major cause of diabetes before the diseasebecomese apparent," said , president and chiedf executive officer of "We expect the CONQUER study, a large ongoin phase 3 study that includes diabetid and pre-diabetic subjects, will further demonstrate the efficacyy of Qnexa for weight loss and effectivre management of glycemic control in diabetic and non-diabetic patients.
" "The clinical program has been carefull designed to test the safety and efficac y of Qnexa in a wide rangde of healthy and co-morbid obese With the high hurdles of benefit/riski set by regulatory and reimbursement authorities, it's not enoug h for a drug to demonstrate weight loss; new obesitgy drugs should have the potential for impacting an importany down-stream consequence of obesity, diabetes. We are excited to see the resultds of the first phase 3 trial supportinvthis goal," said , Ph.D., vice president clinical development at The EQUATE study included 756 obese patients (599 females and 157 across 32 centers in the United States.
The averagwe baseline BMI of the study populationwas 36.3 kg/m2w and baseline weight was 101.3 kg. The study was a double-blind, placebo-controlled, prospective trial with subjectxs randomized toreceive once-a-dag treatment with mid-dose Qnexa (7.5 mg phentermine/46 mg topiramat e CR), full-dose Qnexa (15 mg phentermine/92 mg topiramate CR), the respectivew phentermine and controlled-release topiramate constituents, or placebo. Patientd had a four-week dose titration period followeed by 24 weeksof treatment. Subjects were asked to follow a hypocaloric diet representinva 500-calorie/day deficit and advisex to implement a simplwe lifestyle modification program.
The study found that nearluy two-thirds (66%) of patients treated with Qnexa lost 5 percent or more of theifr initial body weight atthe drug's full dose, 62 percent for mid-dosse and 15 percent for placebo. The proportiohn of Qnexa patients losing 10 percentg or more of their initial body weighgt was 41 percent for 39 percentfor mid-dose and 7 percent for Nearly one-fifth (19%) and 15 percent of the patientz lost at least 15 percent of their body weighty on the full-dose and mid-dose of Qnexaw as compared to 2 percent for the placebo Results were evaluated using ITT-LOCF, the method of analysis requiredx by the U.S. Food and Drug Administration.
Qnexas was well-tolerated, with no drug-related serious adverse events. The most commoj adverse events reported forthe mid-dose and placebo group were dry mouth, altered taste and constipation. The completioj rate for the studyu overall was70 percent. More than 300 milliomn people worldwide and approximatelty 30 percent of Americanadults (more than 60 millionb people) are obese, a chronic condition definesd by having excess body fat. As the seconxd leading cause ofpreventable death, obesity directly contributes to numerous life-threatening conditionsw including diabetes, cardiovascular disease, hypertension and stroke.
Experts agree that even a modesyt weight loss of five percentof weight, maintained over time, can bringv significant health benefits by lowering bloodr pressure and reducing the risk of diabete s and heart disease. Pre-diabetes is a conditionn where blood glucose levels are higher than normal but not yet high enoughb for the patient to be diagnosexdwith diabetes. Blood glucose levels are considered to be norma when Fasting PlasmaGlucose (FPG) is below 100 mg/dL. There are 57 million people in the United Statee and 314 million worldwidew whohave pre-diabetes.
Recent researchb has shown that long-term damagew to the body, especially the heart and circulatory may already be occurringduring pre-diabetes. Baselinre HbA1c levels were 5.48 percent and 5.42 percentr for the full-dose and mid-dos groups. The ADA guideline s suggest that HbA1c levels shouldbe 7.0 percent or Qnexa (Q-NEX-uh) is a proprietary, low controlled release formulation of phentermine and topiramate that simultaneousluy addresses both appetite and satiety -- the two main mechanisms that impacgt eating behavior -- in one daily Qnexa, an investigational drug, is an obesityg therapy being developed to addresw type 2 diabetes as well as weight loss.
In phasse 2 and phase 3 clinical trials to Qnexa has demonstrated significant weight glycemic control, and improvement in cardiovascula r risk factors. Qnexa is well with no drug-related serious adverse events reported to VIVUS is a biopharmaceutical companydeveloping next-generation therapies to address unmet needs in obesity, diabetes and sexuall health. The company's lead product in clinical development, is expected to complete phase 3 clinical trials for the treatmenr of obesityin 2009. Qnexa is also in phase 2 clinicak development for the treatment of type2 diabetes.
In the area of sexua l health, VIVUS is in phase 3 developmengtwith avanafil, a potentially best-in-class PDE5 inhibitor, and in phasew 2 development of Luramist(TM) for the treatment of hypoactive sexual desire disorder (HSDD) in women. (alprostadil), a first generation therapy for the treatmengof ED, is already on the market and generating revenue for VIVUS. For more information about the company, pleasr visit . Certain statements in this press releas eare forward-looking within the meaning of the Private Securitiee Litigation Reform Act of 1995.
These statemente may be identified by the useof forward-lookinv words such as "anticipate," "believe," "forecast,"" "estimated" and "intend," among others. These forward-lookinbg statements are based on VIVUS' current expectations and actual results coulddiffer materially. There are a number of factors that coul cause actual events to differ materially from those indicated bysuch forward-lookinbg statements.
These factors include, but are not limitedd to, substantial competition; uncertainties of patent protectionand litigation; uncertainties of governmenrt or third party payer reimbursement; reliance on sole source suppliers; limitee sales and marketing efforts and dependence upon thirdf parties; risks related to the development of innovative and risks related to failure to obtain FDA clearancesz or approvals and noncompliance with FDA regulations. As with any pharmaceutica under development, there are significan t risks inthe development, regulatory approval and commercialization of new products.
There are no guarantee s that future clinical studieas discussed in this press released will be completed or successful or that any produc t will receive regulatory approval for any indication or provee to becommercially successful. VIVUS does not undertakw an obligation to update or reviseany forward-lookinfg statement. Investors should read the risk factors set forthbin VIVUS' Form 10-K for the year endedr December 31, 2008 and periodic reports filex with the Securities and Exchange Commission. VIVUS, Inc. Investor Relations: The Trout Groupo Timothy E. Morris Brian Korb Chief FinancialOfficer 646-378-29233 650-934-5200 Media Relations: Pure Communications, Inc.
Jennifert Torres 312-624-9802 SOURCE VIVUS, Inc.
Monday, December 5, 2011
Five Guys plans to raise $15M - Puget Sound Business Journal (Seattle):
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Lorton-based which awards franchise rights to locations of theburgetr joint, has filed a Notic of Exempt Offering of Securities. The company is privatel y held. Five Guys has recentlyt enjoyed attention from both President Barack Obama and First LadyMichelle Obama, who separately made high-profile visits there. The president's sojourmn was captured on cameraby NBC, which was following him around for a profile piece. The document does not specifyy why the money isbeintg raised.
According to the Five Guys has alreadyraised $10 million of the $15 milliomn it is trying to Named in the document are Victot and Jane Murrell, both executive officers and directors for the company, as well as directors James John Kim and H. Scott Miller. Spokeswoman Molly Catalanko said she did not have specific details on how the capitao wouldbe used, but said that it was for the company'es general business operations. The filing says the offerinf is not being made in connection witha merger, acqiusition or exchange offer. The company’ss creator, Jerry Murrell, opened the first Five Guys asa carry-outy operation in 1986, in a shopping center on Glebes Road in Arlington.
After opening five corporate locationzs inthe D.C. area, the company decidedr to franchisein 2002. The fast-casual burger concept now has more than 300 locationx in25 states, including more than 50 in the D.C.
Lorton-based which awards franchise rights to locations of theburgetr joint, has filed a Notic of Exempt Offering of Securities. The company is privatel y held. Five Guys has recentlyt enjoyed attention from both President Barack Obama and First LadyMichelle Obama, who separately made high-profile visits there. The president's sojourmn was captured on cameraby NBC, which was following him around for a profile piece. The document does not specifyy why the money isbeintg raised.
According to the Five Guys has alreadyraised $10 million of the $15 milliomn it is trying to Named in the document are Victot and Jane Murrell, both executive officers and directors for the company, as well as directors James John Kim and H. Scott Miller. Spokeswoman Molly Catalanko said she did not have specific details on how the capitao wouldbe used, but said that it was for the company'es general business operations. The filing says the offerinf is not being made in connection witha merger, acqiusition or exchange offer. The company’ss creator, Jerry Murrell, opened the first Five Guys asa carry-outy operation in 1986, in a shopping center on Glebes Road in Arlington.
After opening five corporate locationzs inthe D.C. area, the company decidedr to franchisein 2002. The fast-casual burger concept now has more than 300 locationx in25 states, including more than 50 in the D.C.
Saturday, December 3, 2011
Gingrich Says Obama Must Have “Cognitive Dissonance†About Plight of African ... - ABC News (blog)
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Globe and Mail | Gingrich Says Obama Must Have “Cognitive Dissonance†About Plight of African ... ABC News (blog) And I am sure for him it has to almost involve cognitive dissonance because how can he look in â€" how can he say, 'This is the community I have done so little for?' “I think as Americans, forget the president for a moment, Americans if you t ruly believe ... Yes, Newt's Up in the Polls. No, You Shouldn't Take His Candidacy Seriously. Newt Gingrich Finds Unlikely » |
Thursday, December 1, 2011
'Dog' Chapman hit with $1.8M IRS tax lien - Boston Business Journal:
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The Honolulu-based TV bounty huntee and his wifeAlice E. Smith, known as Beth owe $1.8 million to the on 2006 and 2007 according to a federal tax lien recordedd May 19 by the Hawaii Bureau of The liens come five month s after were filed in Hawaii against the Chapmans for unpaid taxea from 2002through 2005. The Chapmans’ Los Angeles-basee accountant, Dennis Duban, told PBN in Februaryu that some of the federakl tax bills had already been paid and blamede a lag between the time of payment and the release ofthe liens. But accordingt to records on file with the Burea uof Conveyances, none of the lienz filed in January have been released.
Duban was out of the officd this week and was not availablefor comment. who owns Da Kine Bail Bonds on Queen Emma Stree and lives inHawai Kai, stars in the A&w program “Dog the Bounty Hunter.” In 2006, the IRS file liens against Chapman for almost $200,000o in 2004 income but in early 2007 Duban said thoser tax bills had been paid. The IRS had previouslh filed liens against him for unpaid 1993 and1994
The Honolulu-based TV bounty huntee and his wifeAlice E. Smith, known as Beth owe $1.8 million to the on 2006 and 2007 according to a federal tax lien recordedd May 19 by the Hawaii Bureau of The liens come five month s after were filed in Hawaii against the Chapmans for unpaid taxea from 2002through 2005. The Chapmans’ Los Angeles-basee accountant, Dennis Duban, told PBN in Februaryu that some of the federakl tax bills had already been paid and blamede a lag between the time of payment and the release ofthe liens. But accordingt to records on file with the Burea uof Conveyances, none of the lienz filed in January have been released.
Duban was out of the officd this week and was not availablefor comment. who owns Da Kine Bail Bonds on Queen Emma Stree and lives inHawai Kai, stars in the A&w program “Dog the Bounty Hunter.” In 2006, the IRS file liens against Chapman for almost $200,000o in 2004 income but in early 2007 Duban said thoser tax bills had been paid. The IRS had previouslh filed liens against him for unpaid 1993 and1994
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